Women's Reproductive Sciences Research: England Lab
England Lab, Washington University School of Medicine
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sk3-40x-gcl

SK3 channel function in the myometrium

Alterations in ion channel expression and regulation are critical to maintaining uterine quiescence during early gestation, and also lead to increases in uterine excitability at the time of labor.

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BK-recordings

Regulation of BK channels in smooth muscle

Ion channel activity is responsible for changes in the membrane potential in excitable cells; potassium channels play an important role in setting resting membrane potential and in attenuating excitation in smooth muscle cells.

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PLACENTA2_B-(3)

Impact of K channels on pregnancy outcomes

Our lab focuses on the influence of the small conductance Ca2+-activated K+ (SK3) channel on vascular remodeling at the maternal-fetal interface during pregnancy.

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England lab picture 2015

About Us

Dr. England’s research focuses on the question: “Can we advance our understanding of the function of ion channels in smooth muscle such that we can target these structures pharmacologically in the treatment of smooth muscle diseases?” The laboratory has been investigating the roles of potassium channels in regulating both vascular and uterine smooth muscle excitability, with an emphasis primarily on the latter.

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